| چکیده انگلیسی مقاله |
Introduction: This study was designed to evaluate the effects of treatment with flaxseed oil (FSO) on renal ischemia-reperfusion (RIR) injuries in rats. Materials and methods: In this study, 32 Wistar rats were randomly studied in four groups: Co+NS (Control group with normal saline administration), Sh+NS (sham group with normal saline administration), RIR+NS and RIR+FSO. FSO (0.2 ml) was administered orally (gavage) for 14 days (~ 800 mg/kg body weight). Blood samples were collected for the detection of blood urea nitrogen (BUN) and creatinine levels. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were evaluated in the renal tissue. Tubular damages were examined using histopathological studies. Results: Significantly elevated MDA (P< 0.05) and depressed SOD levels (P< 0.05) Comparison between RIR+NS group and Control+NS and Sh+NS groups revealed in the condition of RIR. Treatment with FSO, however, significantly lowered the MDA (P< 0.05) and enhanced SOD levels (P< 0.05) after RIR injury. Histopathological results confirmed the biochemical studies and tubular necrosis score was reduced in the RIR+FSO group. Conclusion: This study therefore suggests that the aqueous flaxseed oil may be useful agents for the prevention of renal ischemia-reperfusion (RIR)-induced oxidative injury in rats. |
| نویسندگان مقاله |
تهمینه مختاری | tahmineh mokhtari
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
هدیه فقیر ghanesefat | hedyeh faghir ghanesefat
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
غلامرضا حسن زاده | gholamreza hassanzadeh
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
اردشیر معیری | ardeshir moayeri
department of anatomy, school of medicine, ilam university of medical sciences, ilam, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)
سید محمد جعفر حایری | seyed mohammad jafar haeri
biology and anatomical sciences, school of medicine, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
علیرضا رضایی kanavee | alireza rezaee kanavee
baharloo hospital, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سید مجید موسوی موحد | seyyed majid mousavi movahed
baharloo hospital, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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