Journal of Basic Research in Medical Sciences، جلد ۷، شماره ۲، صفحات ۱-۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Distinctive deregulation of miR-27a and miR-27b in relapsing remitting multiple sclerosis
چکیده انگلیسی مقاله Introduction: Previous studies have proposed that microRNAs (miRNAs) expression might be responsible for immunological features associated with multiple sclerosis (MS) pathogenesis. We aimed to elucidate the alternation in miR-27a and miR-27b expression in relapsing-remitting multiple sclerosis (RRMS) patients compared to the healthy subjects. Materials and methods: In this study, the expression levels of miR-27a and miR-27b were evaluated in peripheral blood samples of 60 RRMS patients (30 recurrence patients and 30 patients two months after relapse) and 30 healthy subjects by quantitative real-time PCR. Results: The findings indicated that the expression of miR-27a was significantly decreased in recurring patients (P< 0.0001) and two months after relapse patients (P< 0.003) in comparison with healthy subjects. Moreover, miR-27b showed down regulation in recurring patients (P< 0.001) and two months after relapse patients (P< 0.002). Conclusion: The results demonstrated an association between expression of miRNAs studied and RRMS disease during recurrence and two months after relapse. However, further research is warranted to confirm observed associations.
کلیدواژه‌های انگلیسی مقاله microRNA, miR-27a, miR-27b, Multiple sclerosis
نویسندگان مقاله | Jalil Shafiei
Department of Genetic, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Farideh Heidari
Department of Microbiology, Naein Branch, Islamic Azad University, Naein Branch, Naein, Iran


| Elham Khashen
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Falavarjan, Iran


| Rana Ghandehari‐Alavijeh
Graduate Program in Neuroscience, Faculty of Medicine, Laval University, Quebec, QC, Canada


| Zahra Darmishonnejad
Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Iran
نشانی اینترنتی http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-471-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Genetics
نوع مقاله منتشر شده پژوهشی
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