|
|
Journal of Basic Research in Medical Sciences، جلد ۴، شماره ۳، صفحات ۲۶-۳۳
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Induction of apoptosis in human tumor cell lines by platelets |
|
| چکیده انگلیسی مقاله |
Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thrombin-activated platelets. After the elapsed co-culture time, the levels of caspase-3 and CD95 were evaluated as a sign of cell death and apoptosis. In addition, immortalized cells were evaluated using trypan blue, 7-AAD and WST-1 methods. Results: CD95 and caspase-3 levels were significantly increased in both cell lines compared with the control cells (P< 0.05). Beside, considerably lower number of living cells were shown by trypan blue, 7-AAD and WST-1 in the treatment groups compared with the control group (P< 0.05). Conclusion: This study demonstrated the role of apoptosis in tumor inhibition and implied the ability of platelets to induce apoptosis in tumor cell lines. |
|
| کلیدواژه‌های انگلیسی مقاله |
Apoptosis, Platelet, K562, Daudi, CD95 |
|
| نویسندگان مقاله |
مرتضی یافتیان | morteza yaftian
blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran
سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)
فاطمه یاری | fatemeh yari
blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran
سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)
مهران قاسم زاده | mehran ghasemzadeh
blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran
سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)
|
|
| نشانی اینترنتی |
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-212-2&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/358/article-358-332460.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Hematology |
| نوع مقاله منتشر شده |
پژوهشی |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|