| چکیده انگلیسی مقاله |
Introduction: Aerobic training, recognized as a non-pharmacological therapy, can have beneficial effects on improving metabolic conditions and reducing inflammation in patients with type 2 diabetes. This study aimed to investigate the effects of aerobic training on the expression of genes related to sarcopenia signaling pathways, autophagy, and inflammatory markers in a type 2 diabetic rat model.
Materials & Methods: In this experimental study, 30 male Wistar rats aged 12 months, with an average weight of 390 grams (ranging between 380 and 400 grams, ±5 grams SD), were randomly divided into three groups of 10: healthy control, diabetic control (diabetic), and diabetic with exercise. Diabetes was induced using streptozotocin at a dose of 50 mg/kg body weight. The exercise group underwent a moderate-intensity treadmill running program for eight weeks, five sessions per week. Gene expression levels of AKT, FOXO3, Beclin-1, LC3, TNF-α, and IL-1β in the soleus muscle tissue were measured using quantitative real-time PCR. Data analyzed by SPSS V.18 at significance less than 0.05.
Results: Significant differences in the expression levels of AKT, FOXO3, Beclin-1, LC3, TNF-α, and IL-1β among the groups (P=0.000). Gene expression levels were significantly elevated in the diabetic group compared to the healthy group (P=0.000). FOXO3 expression significantly increased in the diabetic group compared to the healthy group and significantly decreased in the exercise group compared to the diabetic group (P=0.000).
Conclusion: Aerobic training can improve muscle function and reduce cell atrophy in type 2 diabetes patients by affecting inflammatory and autophagy pathways, thus serving as an effective strategy for improving metabolic status and preventing cellular damage.
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| نویسندگان مقاله |
محمد حسین ربانی | Mohammad Hossein Rabbani
Dept of Sport Physiology.CT.C. , Islamic Azad University, Tehran, Iran
گروه فیزیولوژی ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران
پروین فرزانگی | Parvin Farzanegi
Dept of Sport Physiology, Sari Branch, Islamic Azad University, Sari,Iran
گروه فیزیولوژی ورزشی، واحد ساری، دانشگاه آزاد اسلامی، ساری، ایران
محمدعلی آذربایجانی | Mohammad Ali Azarbayjani
Dept of Sport Physiology.CT.C. , Islamic Azad University, Tehran, Iran
گروه فیزیولوژی ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران
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