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Journal of Basic Research in Medical Sciences، جلد ۳، شماره ۲، صفحات ۵۳-۵۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A survey of patients with mental retardation of unknown origin |
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| چکیده انگلیسی مقاله |
Introduction: Fragile X syndrome (FXS) is one of the most prevalent genetic causes of developmental disability, representing the most frequent form of inherited severe cognitive deficit. The present study was undertaken to investigate FXS and its prevalence in moderate mentally retarded people in patients. Materials and methods: Nineteen people with moderate mental retardation (MR) who were clinically suspicious to have FXS were screened for FXS by using cytogenetic and molecular methods. Blood samples were collected and cultured in specific culture media. G-Banding method was used for karyotyping. To ensure correct results of cytogenetic testing, four suspected case of FXS were tested by PCR. Results were analyzed using logistic regression analysis. Results: Four patients (4%) were found to express fragile X site at q27.3. The results showed that the relationship of FXS with familial, economic status was not significant, but the relationship of FXS with MR and family history was significant. Conclusion: The frequency of FXS positive cases found in this study is similar to other reports of FXS in preselected patients. |
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| کلیدواژه‌های انگلیسی مقاله |
MR, FXS, FMR1, Cytogenetic |
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| نویسندگان مقاله |
افشین یارمحمدی | afshin yarmohammadi
department of biology, sanandaj branch, islamic azad university, kurdistan, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
فاطمه کشاورزی | fatemeh keshavarzi
department of biology, sanandaj branch, islamic azad university, kurdistan, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
مختار فرهادیان | mokhtar farhadian
department of psychology, sanandaj branch, islamic azad university, sanandaj, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
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| نشانی اینترنتی |
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-168-1&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/358/article-358-120432.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Genetics |
| نوع مقاله منتشر شده |
پژوهشی |
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