Journal of Basic Research in Medical Sciences، جلد ۲، شماره ۲، صفحات ۳۰-۳۶

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عنوان انگلیسی Hydroalcoholic Extract of Matricaria chamomilla effectively reduces inflammation induced by xylene in rat
چکیده انگلیسی مقاله Introduction: Due to side effects of antiinflammatory drugs such as dexamethasone and indomethacin, there is a less tendency to use them. On the other hand, the use of medicinal plants has been common in the treatment of inflammation since ancient times and also, using of the plants is increasing. Present research investigated the antiinflammatory effect of the hydroalcoholic extract of capitols of Matricaria chamomilla (M. chamomilla) in rat. Materials and methods: The hydroalcoholic extract of capitols of M. chamomilla [(at the doses of 500, 1000 and 1500 mg/kg BW (body weight)] and dexamethasone and indomethacin (at the dose of 15 mg/kg BW) were intraperitoneally injected to the rats. The weights of the ears of animal after induced inflammation by xylene and then, after the mentioned treatments were set as indices of antiinflammatory effects. Results: Hydroalcoholic extract of the capitols of M. chamomilla at the dose of 1500 mg/kg BW significantly reduced the xylene induced inflammation in the rats (P< 0.01). Also, hydro-alcoholic extract of the herb at the doses of 500, 1000, and 1500 mg/kg BW significantly reduced the acetic acid induced inflammatory pain (P< 0.001). Conclusion: The extract of the capitols of M. chamomilla have antiinflammatory effects that is comparative to the antiinflammatory effects of traditional antiinflammatory drugs such as dexamethasone and indomethacin.
کلیدواژه‌های انگلیسی مقاله Matricaria chamomilla, Inflammation, Rat

نویسندگان مقاله منصور امرایی | mansour amraei
department of clinical physiology, faculty of medicine


فهمیده بگرضایی | fahmideh bagrezaei
department of clinical biochemistery, faculty of allied medical sciences


حمید تقی نژاد | hamid taghinejad
department of clinical biochemistery, faculty of allied medical sciences


صفورا محمدپور | safoura mohamadpour
department of clinical biochemistery, faculty of medicine


فرج اله ملکی | farajolah maleki
department of clinical physiology, faculty of medicine



نشانی اینترنتی http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-102-6&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Physiology
نوع مقاله منتشر شده پژوهشی
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