Plant Biotechnology Persa، جلد ۴، شماره ۱، صفحات ۵۶-۶۲

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عنوان انگلیسی Does Dietary Monosodium Glutamate Cause Neuro-toxicity on The Central Nervous System? A Review
چکیده انگلیسی مقاله
Monosodium glutamate (MSG) is an additive which is substantially applied in commercially processed foods in order to increase the flavor and sapidity and make a unique flavor which cannot be provided by any other ingredient. Since the discovery of endogenous amino acid glutamate (as a neurotransmitter) in human body, the possible toxicity of exogenous glutamic acid has attracted the attention of numerous scholars. Accordingly, various animal studies have been documented on toxic impacts of MSG on different parts of the body including central nervous system, liver, adipose tissue, reproductive organs, and other systems. Thus, since that time, the safety of MSG has repeatedly been checked and reaffirmed within the scientific communities due to the contradict results. This literature review article specifically aimed to discuss the probable safety of dietary MSG for central nervous system and also provide an integrated information from several studies documented on possible neurotoxic effects of monosodium glutamate on glutamate receptors of Central Nervous System in order to elevate the public awareness about it. Collecting the results of all studied articles seems to supports the hypothesis of safety. In fact, it seems that MSG as a food additive within the limited amounts as well as natural levels of glutamic acid which is present in food supplies provides no serious hazard to the human CNS.

 
کلیدواژه‌های انگلیسی مقاله CNS,Food additives,Hypothalamus,Pituitary,Monosodium glutamate,Neurotoxicity.

نویسندگان مقاله | Shiva Ghareghani
Pharmacology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Parisa Sadighara
Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Sayedeh Mahsa Khodaei
Department of Nutrition, Health and Food Safety, Isfahan University of Medical Sciences, Isfahan, Iran


| Mohadeseh Pirhadi
Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.



نشانی اینترنتی http://pbp.medilam.ac.ir/browse.php?a_code=A-10-91-5&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical
نوع مقاله منتشر شده کاربردی
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