Journal of Basic Research in Medical Sciences، جلد ۴، شماره ۴، صفحات ۸-۱۲

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عنوان انگلیسی Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings
چکیده انگلیسی مقاله Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding. Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group. Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients. Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.
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نویسندگان مقاله اسماعیل رستمی | esmaeil rostami
department of laboratory sciences, faculty of paramedicine, sabzevar university of medical sciences, sabzevar, iran


حسین آیت اللهی | hossein ayatollahi
cancer molecular pathology research center, department of hematology and blood bank, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حسن بوستانی | hassan boustani
department of hematology, school of allied medical sciences, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

عباس قوطاسلو | abbas ghotaslou
department of hematology, school of allied medical sciences, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمد هادی صادقیان | mohammad hadi sadeghian
neonatal research center, imam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمدرضا کرامتی | mohammad reza keramati
neonatal research center, imam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

الهه زینالی | elahe zeinali
department of laboratory sciences, faculty of paramedicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ابوالفضل راد | abolfazl rad
department of biochemistry and nutrition, cellular and molecular research center, sabzevar university of medical sciences, sabzevar, iran



نشانی اینترنتی http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-271-1&slc_lang=en&sid=en
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Hematology
نوع مقاله منتشر شده پژوهشی
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