Journal of Basic Research in Medical Sciences، جلد ۴، شماره ۴، صفحات ۱۳-۱۷

عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی The prevalence of chromosomal translocation t (1; 4) (p21; p14) in Iranian patients with mental disability
چکیده انگلیسی مقاله Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70 and has a limitation in one or multiple adaptive skills. There are many different causes of intellectual disability that one of them is the genetically and chromosomal abnormalities. The aim of this paper was to study translocation breakout t (1; 4) (p21; p14) in a number of mental retardation patients in Iran. Materials and methods: This descriptive study was carried out on 100 persons with light mental disability by using cytogenetic methods. Lymphocytes were cultured in the dedicated environment by G-Banding karyotype of each person after obtaining patient’s blood sample. The data were statistically analyzed by logistic regression. Results: The findings showed that none of the patients with a mental disability was afflicted to the chromosomal translocation, (1; 4) (p21; p14). Conclusion: The lack of translocation in this study was equivalent with the obtained frequency in the same studies which have been carried out on the subjects suspected to have a translocation. Also, it seems that chromosomal analysis may be a usefulness diagnostic tool for children with mental retardation.
کلیدواژه‌های انگلیسی مقاله Mental disability, Translocation, Karyotype

نویسندگان مقاله پگاه وثوقی | pegah vosoughi
1department of biology, kurdistan science and research branch, islamic azad university, sanandaj, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

فاطمه کشاورزی | fatemeh keshavarzi
department of genetics, sanandaj branch, islamic azad university, sanandaj, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

پرویز اشتری | parviz ashtari
radiation application research school, nuclear science and technology research institute, tehran, iran

نشانی اینترنتی
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Genetics
نوع مقاله منتشر شده پژوهشی
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