Journal of Basic Research in Medical Sciences، جلد ۵، شماره ۱، صفحات ۱-۹
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چکیده فارسی مقاله
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عنوان انگلیسی Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat
چکیده انگلیسی مقاله Introduction: Burn is among the traumas that impose great physical and psychological damages to the injured people. Scientists still are looking for new treatments and methods for burn management that lack the defects of previous ones. Recently, the potential of probiotic bacteria for the treatment of skin disease and problems has been investigated. Considering that the effects of probiotics are strain-dependent, the aim of current study was to evaluate the effects of Lactobacillus rhamnosus (ATCC 7469) on the process of burn wound healing. Materials and methods: After induction of second-degree burn wounds on the back of rats, they were randomly divided into experimental, vehicle control, and negative control groups. The experimental groups received a bacterial ointment for 1, 3, 7, and 14 days. The vehicle control groups received Eucerin for durations like the experimental groups. The negative control groups received no treatment in the same days. The evaluation of wound healing was conducted macroscopically by computing of the healing percent and microscopically by Hematoxylin and Eosin staining of the tissue samples of the wound area on different days. Results: The wound healing percent in the experimental group, compared with control groups, significantly increased, until the day 7 of the experiments. Moreover, the microscopic results indicate that the bacteria may have some anti-inflammatory effects. Also, the bacteria increased the rate of fibroblastic migration and re-epithelialization in the wound area. Conclusion: Overall, L. rhamnosus (ATCC 7469) when used topically on the burn wounds may have some positive effects on the process of burn wound healing.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله امیر عباس برزگری | amir abbas barzegari
department of biology, faculty of basic science, university of maragheh, maragheh, iran


مسعود هاشمزایی | masood hashemzaei
department of biology, faculty of basic science, university of maragheh, maragheh, iran


علیرضا علی همتی | ali reza alihemmati
department of histology and embryology, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

سروش سلطانی | soroush soltani
department of biology, faculty of basic science, university of maragheh, maragheh, iran


بهروز ناصری | behrouz naseri
department of biology, faculty of basic science, university of maragheh, maragheh, iran
نشانی اینترنتی http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-320-1&slc_lang=en&sid=en
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Microbiology
نوع مقاله منتشر شده پژوهشی
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